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Mechanism of glutathionylation of the active site thiols of peroxiredoxin 2

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Peroxiredoxin 2 (Prdx2) undergoes ready glutathionylation, and glutaredoxin-catalyzed deglutathionylation provides an alternative mechanism to thioredoxin/thioredoxin reductase for recycling the reduced protein (Peskin et al JBC 216, 3053, 2016). To elucidate ... ...