Objective: Intravascular large B-cell lymphoma (IVLBCL) is a rare and aggressive lymphoma that can have heterogeneous central nervous system involvement and cerebrovascular complications. The development of IVLBCL can be fatal. Although relatively rare, the development of specific clinical syndromes, such as IVLBCL, has been implicated following infection and vaccination. To our knowledge, this is the first comprehensive neuropsychological evaluation assessing neurocognitive and psychological status after IVLBCL diagnosis.

Methods: The current study presents a right-handed mid-60-year-old male with a university-level education, who was diagnosed with IVLBCL following viral vector SARS-CoV-2 vaccination. He presented with a complex medical history including antiphospholipid syndrome, deafness (prior to cochlear implant), and cardiovascular complications secondary to lymphoma. Brain magnetic resonance imaging showed parietal, frontal, and cerebellar infarcts; encephalomalacia; and periventricular deep chronic ischemic changes. A comprehensive neuropsychological evaluation was completed.

Results: In consideration of an individual with an estimated above-average baseline, his neurocognitive profile demonstrated impairments across multiple domains that were more lateralized to the non-dominant hemisphere including visual attention, visual processing speed, visuo-construction, memory, motor dexterity, and right-sided ataxia (e.g., dysmetria). Clinical elevations for depression, hopelessness, and anxiety were also found.

Conclusions: The current study highlights a novel cognitive profile of IVLBCL and comorbidities with the patient having more predominant nondominant hemispheric-related deficits. There was evidence of disruption to visual processing networks, largely consistent with neuroimaging lesions. The current case also describes the unique experience of an individual coping with a rare condition, especially when resulting in functional decline (e.g., loss of audition). Implications are discussed.

Keywords: COVID-19; Cancer; Cognitive functioning; IVLBCL; Intravascular large B-cell lymphoma.

© The Author(s) 2025. Published by Oxford University Press.

目标：

目标: 髓系来源的大B细胞淋巴瘤（IVLBCL）是一种罕见且具有侵袭性的淋巴瘤，可导致中枢神经系统异质性受累和脑血管并发症。IVLBCL的发展可能是致命的。尽管相对罕见，但感染和疫苗接种后可能会出现特定临床综合征如IVLBCL。据我们所知，这是首次对IVLBCL诊断后的神经心理状态进行全面的认知和心理评估。

方法：

方法: 当前研究介绍了一名右手惯用的中年男性患者（大学教育水平），他在接受SARS-CoV-2病毒载体疫苗接种后被诊断出患有IVLBCL。他有复杂的病史，包括抗磷脂综合征、耳聋（在植入人工耳蜗之前）和由于淋巴瘤导致的心血管并发症。脑部磁共振成像显示顶叶、额叶和小脑梗塞；脑软化症；以及周围室深部慢性缺血性改变。进行了全面的神经心理评估。

结果：

结果: 在考虑一个估计基线水平较高的个体的情况下，他的神经认知状况在多个领域表现出损害，这些损害主要集中在非优势半球，包括视觉注意力、视觉处理速度、视知觉构建能力、记忆、运动灵巧性和右侧共济失调（例如，失用症）。临床评估还发现抑郁、绝望和焦虑的水平升高。

结论：

结论: 当前研究强调了IVLBCL及其伴随疾病的新认知模式，患者有更显著的非优势半球相关的缺陷。视觉处理网络受损的证据与神经影像学病变基本一致。当前案例还描述了一名个体应对罕见病症的独特经历，尤其是在导致功能下降（例如听力丧失）的情况下。讨论了其意义。

关键词：

关键词: COVID-19；癌症；认知功能；IVLBCL；髓系来源的大B细胞淋巴瘤。