Early diagnosis of liver fibrosis remains a challenge. The aim of this study was to compare the performance of the GPR, APRI and FIB-4 scores in the diagnosis of significant fibrosis in chronic hepatitis B. This was a 6-month cross-sectional study. Patients were aged 18 and over, had a FibroScan® and had venous blood samples taken. 133 patients were included. The mean FibroScan® value was 5.33 ± 0.47 kPa, with 26.32% showing significant fibrosis (>7.2 kPa). The GPR score had a sensitivity of 80% compared with 48.57% and 51.42% respectively for the APRI and FIB-4 scores. However, its specificity was lower (51.02%) compared with the APRI (77.55%) and FIB-4 (81.63%) scores. The area the ROC curve of the GPR score (0.760) was higher than that of the APRI (0.712) and FIB-4 (0.724) scores in predicting significant fibrosis (p < 0.05). The GPR score is more accurate for assessing liver fibrosis in chronic hepatitis B in sub-Saharan Africa.

Keywords: APRI score; FIB-4 score; GPR score; chronic hepatitis B; liver fibrosis.

早期诊断肝纤维化仍然是一项挑战。本研究的目的是比较GPR、APRI和FIB-4评分在慢性乙型肝炎患者中诊断显著纤维化的性能。这是一项为期6个月的横断面研究。纳入患者的年龄为18岁及以上，进行了FibroScan®检查，并采集了静脉血液样本。共纳入了133名患者。平均FibroScan®值为5.33 ± 0.47 kPa，其中26.32%的患者表现出显著纤维化（>7.2 kPa）。GPR评分的敏感性为80%，而APRI和FIB-4评分的敏感性分别为48.57%和51.42%。然而，其特异性较低（51.02%），相比之下，APRI评分为77.55%，FIB-4评分为81.63%。GPR评分的ROC曲线下的面积为0.760，高于APRI (0.712) 和 FIB-4 (0.724) 评分在预测显著纤维化中的表现（p < 0.05）。在非洲撒哈拉以南地区慢性乙型肝炎患者中，GPR评分更准确地评估肝纤维化。

关键词： APRI评分；FIB-4评分；GPR评分；慢性乙型肝炎；肝纤维化。