Current microbiology. 2025 Apr 6;82(6):234. doi: 10.1007/s00284-025-04214-0 Q32.62025
Bioactive Fraction of Streptomyces thinghirensis MSA1 Effectively Inhibits Biofilm Forming Clinically Significant AMR Pathogens
产碳青霉烯酶肺炎克雷伯菌的流行现状及分子特征分析 翻译改进
S Aifa Fathima 1, A Yaser Arafath 1, Ragothaman Prathiviraj 1, Saqib Hassan 2, George Seghal Kiran 3, Joseph Selvin 4
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DOI: 10.1007/s00284-025-04214-0 PMID: 40188414
摘要 中英对照阅读
抗生素耐药微生物威胁日益加剧，需要发现新的抗菌剂。本研究探索了与海洋相关的放线菌的潜力，并重点关注从印度帕尔克湾的海绵Callyspongia diffusa中分离出的链霉菌Streptomyces thinghirensis MSA1，因其显著的抗菌特性而备受关注。为了优化MSA1生物活性化合物的生产，我们建立了最佳生长条件（30°C、pH 7、2%盐度、9天培养）并使用ISP4培养基来增强次级代谢产物的产生。通过FTIR和GCMS分析提取的化合物MSA1，识别出20种具有生物活性的组分。MSA1对包括大肠杆菌、肺炎克雷伯氏菌、伤寒沙门氏菌、铜绿假单胞菌和耐甲氧西林金黄色葡萄球菌在内的重要病原体显示出强大的抗菌活性，并且还表现出显著的抗氧化和抗生物膜特性。这些发现突显了MSA1作为开发对抗抗生素耐药感染治疗候选药物的潜力。本研究承认该研究结果的初步性质，强调需要进一步进行体内及临床试验以完全确定MSA1的治疗潜力。这项研究为在抗击抗生素耐药性的斗争中寻找新的抗菌剂开辟了途径，并突显了海洋生物多样性在医学科学中的价值。
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