Two-Step Synthesis of a Dolutegravir Intermediate DTG-6 in a Microfluidized Bed Cascade System: Route Design and Kinetic Study
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In the existing two-step method for the preparation of DTG-6 (i.e., an important intermediate of the anti-HIV drug Dolutegravir (DTG)), a strong base is required to neutralize the homogeneous strong acid catalyst of the first step to make the reaction solution... ...
