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Nature communications. 2025 Mar 31;16(1):3089. doi: 10.1038/s41467-025-58254-y Q114.72024

Repair-associated macrophages increase after early-phase microglia attenuation to promote ischemic stroke recovery

与修复相关的巨噬细胞在早期阶段的微胶质细胞减弱后增加以促进缺血性中风恢复 翻译改进

Xiaotao Zhang  1  2  3  4, Huaming Li  1  2  4, Yichen Gu  1  2, An Ping  1  2, Jiarui Chen  1  2, Qia Zhang  1  2, Zhouhan Xu  1  2, Junjie Wang  1  2, Shenjie Tang  1  2, Rui Wang  1  2, Jianan Lu  1  2  4, Lingxiao Lu  1  2, Chenghao Jin  1  2, Ziyang Jin  1  2, Jianmin Zhang  5  6  7  8, Ligen Shi  9  10  11

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作者单位

  • 1 Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
  • 2 Clinical Research Center for Neurological Diseases of Zhejiang Province, Hangzhou, China.
  • 3 Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
  • 4 State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China.
  • 5 Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. zjm135@zju.edu.cn.
  • 6 Clinical Research Center for Neurological Diseases of Zhejiang Province, Hangzhou, China. zjm135@zju.edu.cn.
  • 7 Brain Research Institute, Zhejiang University, Hangzhou, Zhejiang, China. zjm135@zju.edu.cn.
  • 8 Research Center for Life Science and Human Health, Binjiang Institute of Zhejiang University, Hangzhou, China. zjm135@zju.edu.cn.
  • 9 Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. slg0904@zju.edu.cn.
  • 10 Clinical Research Center for Neurological Diseases of Zhejiang Province, Hangzhou, China. slg0904@zju.edu.cn.
  • 11 Research Center for Life Science and Human Health, Binjiang Institute of Zhejiang University, Hangzhou, China. slg0904@zju.edu.cn.

    • DOI: 10.1038/s41467-025-58254-y PMID: 40164598

    摘要 Ai翻译

    Ischemic stroke recovery involves dynamic interactions between the central nervous system and infiltrating immune cells. Peripheral immune cells compete with resident microglia for spatial niches in the brain, but how modulating this balance affects recovery remains unclear. Here, we use PLX5622 to create spatial niches for peripheral immune cells, altering the competition between infiltrating immune cells and resident microglia in male mice following transient middle cerebral artery occlusion (tMCAO). We find that early-phase microglia attenuation promotes long-term functional recovery. This intervention amplifies a subset of monocyte-derived macrophages (RAMf) with reparative properties, characterized by high expression of GPNMB and CD63, enhanced lipid metabolism, and pro-angiogenic activity. Transplantation of RAMf into stroke-affected mice improves white matter integrity and vascular repair. We identify Mafb as the transcription factor regulating the reparative phenotype of RAMf. These findings highlight strategies to optimize immune cell dynamics for post-stroke rehabilitation.

    Keywords：ischemic stroke recovery; macrophages; microglia attenuation

    关键词：缺血性卒中恢复; 巨噬细胞; 小胶质细胞减弱

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    期刊名：Nature communications

    缩写：NAT COMMUN

    ISSN：2041-1723

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    IF/分区：14.7/Q1

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    Repair-associated macrophages increase after early-phase microglia attenuation to promote ischemic stroke recovery