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Hypothermia treatment in HIF-1α knock-out mice with hypoxia-ischemia

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Introduction: Hypoxia-inducible factor-1α (HIF-1α) has a wide-ranging role in the cellular responses to hypoxia. We previously found that neuron-specific HIF-1α deficient mice (HIF-KO) that underwent neonatal hypoxia-ischemia ... ...