首页 文献索引 SCI期刊 AI助手
登录 注册
首页 正文

Proceedings of the Japan Academy. Series B, Physical and biological sciences. 2025 Mar 31. doi: 10.2183/pjab.101.016 Q24.42024

Conformational dynamics and molecular interactions of natural products: unveiling functional structures in biological membranes

天然产物的构象动力学和分子相互作用:揭示生物膜中的功能结构 翻译改进

Michio Murata  1  2  3, Masayuki Satake  4, Nobuaki Matsumori  5

作者单位 +展开

作者单位

  • 1 Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan.
  • 2 Institute for Protein Research, Osaka University, Suita, Osaka, Japan.
  • 3 Forefront Research Center, Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan.
  • 4 Department of Chemistry, School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
  • 5 Department of Chemistry, Graduate School of Science, Kyushu University, Nishi-ku, Fukuoka, Japan.
  • DOI: 10.2183/pjab.101.016 PMID: 40159185

    摘要 Ai翻译

    Structural studies of natural products have been a driving force in the development of organic chemistry throughout its long history, especially in the early years. Recently, structure determination based on new concepts has also gained momentum. In this review we will mainly discuss the functional structures of natural products that account for the mechanisms of action largely from our studies. The topics include marine natural products, amphidinols, and ladder-shaped polyether compounds, which are known as potent antifungal agents and important marine biotoxins, respectively. Nuclear magnetic resonance studies for determining the stereochemistry of amphidinol 3 and its conformation in lipid-bilayer membranes will be presented in detail.

    Keywords: amphidinol; brevisulcatic acid; functional structure; lipid bilayer; natural product chemistry; solid-state NMR.

    Keywords:conformational dynamics; molecular interactions; natural products; biological membranes

    Copyright © Proceedings of the Japan Academy. Series B, Physical and biological sciences. 中文内容为AI机器翻译,仅供参考!

    相关内容

    期刊名:Proceedings of the japan academy series b-physical and biological sciences

    缩写:P JPN ACAD B-PHYS

    ISSN:0386-2208

    e-ISSN:1349-2896

    IF/分区:4.4/Q2

    文章目录 更多期刊信息

    全文链接
    引文链接
    复制
    已复制!
    推荐内容
    Conformational dynamics and molecular interactions of natural products: unveiling functional structures in biological membranes