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Review Antiviral research. 2025 Mar 27:106153. doi: 10.1016/j.antiviral.2025.106153 Q14.52024

Hijacking JAKis: JAK inhibitors as potential antiviral molecules, a mini review

劫持JAK抑制剂：作为潜在抗病毒分子的JAK抑制剂，一篇简短评论 翻译改进

Claudie Eber  1, Eloi R Verrier  2

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作者单位

  • 1 University of Strasbourg, Inserm, ITM UMR_S1110, Strasbourg, France.
  • 2 University of Strasbourg, Inserm, ITM UMR_S1110, Strasbourg, France. Electronic address: e.verrier@unistra.fr.

    • DOI: 10.1016/j.antiviral.2025.106153 PMID: 40157651

    摘要 Ai翻译

    Janus kinases (JAKs) are key players in the innate immune response and inflammation, catalysing the phosphorylation of STAT proteins, which ultimately leads to the expression of pro-inflammatory and antimicrobial genes. In this context, specific inhibitors of JAK kinases, or JAKis, have been extensively developed, with some already in clinical use for the treatment of chronic inflammatory diseases. However, the interactions between JAK kinases and viral replication appear to be far more complex than initially expected, with some JAKis showing unexpected antiviral properties against different classes of viruses. This mini review summarizes current knowledge about the interactions between JAK proteins and viral infections and discusses the antiviral potential of JAK inhibitors in the development of innovative therapeutic strategies.

    Keywords：JAK inhibitors; potential antiviral molecules

    关键词：Janus激酶抑制剂; 潜在的抗病毒分子

    Copyright © Antiviral research. 中文内容为AI机器翻译，仅供参考！

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    期刊名：Antiviral research

    缩写：ANTIVIR RES

    ISSN：0166-3542

    e-ISSN：1872-9096

    IF/分区：4.5/Q1

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