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Review Mathematical biosciences and engineering : MBE. 2025 Feb 13;22(2):431-476. doi: 10.3934/mbe.2025017 Q20.02024

Computational modeling of peritoneal dialysis: An overview

腹膜透析的计算建模:综述 翻译改进

Sangita Swapnasrita  1  2, Joost C de Vries  2, Carl M Öberg  3, Aurélie Mf Carlier  1, Karin Gf Gerritsen  2

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作者单位

  • 1 MERLN Institute for Regenerative Medicine, Maastricht University, Universiteitssingel 40, 6229 ER Maastricht, The Netherlands.
  • 2 Department of Nephrology and Hypertension, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
  • 3 Department of Clinical Sciences Lund, Division of Nephrology, Skåne University Hospital, Lund, University, Lund, Sweden.
  • DOI: 10.3934/mbe.2025017 PMID: 40083302

    摘要 Ai翻译

    Peritoneal dialysis (PD) is a kidney replacement therapy for patients with end-stage renal disease. It is becoming more popular as a result of a rising interest in home dialysis. Its effectiveness depends on several physiological and technical factors, which have led to the development of various computational models to better understand and predict PD outcomes. In this review, we traced the evolution of computational PD models, discussed the principles underlying these models, including the transport kinetics of solutes, the fluid dynamics within the peritoneal cavity, and the peritoneal membrane properties, and reviewed the various PD models that can be used to optimize and personalize PD treatment. By providing a comprehensive overview, we aim to guide both current clinical practice and future research into novel PD techniques such as the application of continuous flow and sorbent-based dialysate regeneration where mathematical modeling may offer an inexpensive and effective tool to optimize design of these novel techniques at a patient specific level.

    Keywords: mathematical modeling; parameter determination; peritoneal dialysis; solute flux; volume flux.

    Keywords:peritoneal dialysis; computational modeling

    关键词:腹膜透析; 计算建模

    Copyright © Mathematical biosciences and engineering : MBE. 中文内容为AI机器翻译,仅供参考!

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    期刊名:Mathematical biosciences and engineering

    缩写:MATH BIOSCI ENG

    ISSN:1547-1063

    e-ISSN:1551-0018

    IF/分区:0.0/Q2

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