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Signal transduction and targeted therapy. 2025 Mar 14;10(1):86. doi: 10.1038/s41392-025-02172-4 Q140.82024

Breaking down KRAS: small-molecule degraders for cancer therapy

KRAS的分解：用于癌症治疗的小分子降解物 翻译改进

Tina Kos  1  2  3, Dieter Saur  4  5  6  7

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作者单位

  • 1 Chair of Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany.
  • 2 Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheim Feld 280, 69120, Heidelberg, Germany.
  • 3 Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Einsteinstr. 25, 81675, Munich, Germany.
  • 4 Chair of Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany. dieter.saur@tum.de.
  • 5 Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheim Feld 280, 69120, Heidelberg, Germany. dieter.saur@tum.de.
  • 6 Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Einsteinstr. 25, 81675, Munich, Germany. dieter.saur@tum.de.
  • 7 Department of Internal Medicine II, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany. dieter.saur@tum.de.

    • DOI: 10.1038/s41392-025-02172-4 PMID: 40082410

    摘要 中英对照阅读

    Keywords：small-molecule degraders; cancer therapy

    关键词：小分子降解剂; 癌症治疗

    Copyright © Signal transduction and targeted therapy. 中文内容为AI机器翻译，仅供参考！

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    期刊名：Signal transduction and targeted therapy

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    ISSN：2095-9907

    e-ISSN：2059-3635

    IF/分区：40.8/Q1

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    Breaking down KRAS: small-molecule degraders for cancer therapy