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The Central Composite Design and Artificial Neural Network Coupled with Genetic Algorithm in Optimization and Modeling of the Radiolabeling Process of 177Lu-hydroxyapatite as a Potential Radiosynovectomy Agent

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Background: A promising material used in radiation synovectomy of small joints is hydroxyapatite, labeled with 177Lu. During the design and production of radiopharmaceuticals, the condition of the radiolabeling process directly i... ...