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Modeling and optimization of docosahexaenoic acid production by Schizochytrium sp. based on kinetic modeling and genetic algorithm optimized artificial neural network

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Docosahexaenoic acid (DHA), an essential ω-3 polyunsaturated fatty acid, is efficiently biosynthesized by Schizochytrium sp., yet its bioprocess optimization remains constrained by dynamic interdependencies between cultivation parameters and metabolic shifts.... ...