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Selumetinib use as targeted therapy for plexiform neurofibroma: a comprehensive review of the literature

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Neurofibromatosis type 1 is inherited in an autosomal dominant fashion. The approximate prevalence of neurofibromatosis type 1 is 1:2500 to 1:3500 regardless of ethnic group. Around 50% of neurofibromatosis type 1 patients develop plexiform neurofibroma, a les... ...