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Journal of the Academy of Consultation-Liaison Psychiatry. 2025 Feb 18:S2667-2960(25)00025-4. doi: 10.1016/j.jaclp.2025.02.003 Q22.52025

Unnecessary Use of Medications for Alcohol Withdrawal among Hospitalized Patients: A Retrospective Study of Phosphatidylethanol Testing in Patients with Suspected Alcohol Use Disorder

对住院患者不必要的酒精戒断药物使用：磷脂乙醇检测在疑似酗酒障碍患者中的回顾性研究 翻译改进

Pooja R Sarkar  1, Amber N Edinoff  2, Joji Suzuki  3

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作者单位

  • 1 Department of Psychiatry, Beth Israel Deaconess Hospital, Boston, MA; Harvard Medical School, Boston, MA. Electronic address: prsarkar@bidmc.harvard.edu.
  • 2 Harvard Medical School, Boston, MA; Division of Alcohol, Drugs, and Addiction, McLean Hospital, Belmont, MA.
  • 3 Harvard Medical School, Boston, MA; Department of Psychiatry, Brigham and Women's Hospital, Boston, MA.

    • DOI: 10.1016/j.jaclp.2025.02.003 PMID: 39978639

    摘要 Ai翻译

    Objectives: Alcohol withdrawal is frequently encountered in hospital settings, but the decision to treat the withdrawal with pharmacotherapy is often made without knowing if treatment is even necessary. Testing for phosphatidylethanol (PEth), results of which correlate well with recent alcohol consumption, may allow hospital teams to avoid treating alcohol withdrawal unnecessarily. To investigate PEth values of those suspected of AWS among hospital inpatients, we conducted a retrospective study to determine the prevalence of hospitalized patients who received pharmacotherapy for withdrawal who also demonstrated PEth values suggesting minimal recent drinking.

    Methods: This retrospective study examined the electronic health records of hospitalized adult patients suspected of recent heavy alcohol use for whom PEth tests were ordered. PEth tests were ordered at the time to inform treatment decisions such as the provision of naltrexone or referral to ongoing psychosocial treatments, but not to inform the decision to treat AWS given that results would only be available 3 or more days later. Hospital inpatients, excluding emergency room encounters, for whom PEth was ordered at two affiliated academic hospitals from January 2021 to April 2024 were included.

    Results: The included cohort was composed of 73 individual encounters. Among the 45 (62%) encounters where pharmacotherapy for AWS was administered, 14 (31%) had PEth values (≤200ng/ml) inconsistent with heavy alcohol use.

    Conclusions: Results suggest that a substantial proportion of hospital inpatients may have received pharmacotherapy for AWS despite PEth levels inconsistent with recent heavy alcohol use. If PEth results are available in real-time, results could help clinicians decide if pharmacotherapy is warranted. Further study of PEth testing and its role in the care of hospitalized patients is recommended.

    Keywords: PEth; alcohol use disorder; alcohol withdrawal.

    Keywords：Alcohol Withdrawal; Phosphatidylethanol Testing; Suspected Alcohol Use Disorder

    关键词：酒精戒断; 磷脂酰乙醇检测; 疑似酗酒障碍

    Copyright © Journal of the Academy of Consultation-Liaison Psychiatry. 中文内容为AI机器翻译，仅供参考！

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    期刊名：Journal of the academy of consultation-liaison psychiatry

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    ISSN：2667-2960

    e-ISSN：2667-2960

    IF/分区：2.5/Q2

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    Unnecessary Use of Medications for Alcohol Withdrawal among Hospitalized Patients: A Retrospective Study of Phosphatidylethanol Testing in Patients with Suspected Alcohol Use Disorder