Discovery of a selective and reversible LSD1 inhibitor with potent anticancer effects in vitro and in vivo
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Lysine-specific demethylase 1 (LSD1) is abnormally overexpressed in various tumour tissues of patients and has been an attractive anticancer target. In this work, a potent LSD1 inhibitor (compound 14) was designed and synthesised by the molecular hybridisation... ...
