Promoting the glycosylation of drug-like natural products in a Saccharomyces cerevisiae chassis by deletion of endogenous glycosidases
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Glycosylation is an effective strategy to improve the absorption, distribution, metabolism, excretion, and toxicity of natural product (NP) pharmacophores. While heterologous production of broad-spectrum fungal glucosyltransferases such as BbGT86 of Beauveria ... ...