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Diagnostic and interventional imaging. 2025 Feb 13:S2211-5684(25)00009-9. doi: 10.1016/j.diii.2025.02.001 Q18.12025

Ethylene-vinyl alcohol copolymer-based non-adhesive liquid embolic agent for transcatheter arterial embolization in patients with abdominal/pelvic arterial bleeding: A prospective, single-arm, multicenter cohort study

基于乙烯-乙烯醇共聚物的非粘附性液态栓塞剂在腹盆动脉出血患者经导管动脉栓塞术中的应用：一项前瞻性、单臂、多中心队列研究 翻译改进

Romaric Loffroy  1, Hicham Kobeiter  2, Vincent Vidal  3, Julien Frandon  4, Olivier Pellerin  5, Carole Dean  6, Skander Sammoud  4, Hélène Vernhet-Kovacsik  7, Haytham Derbel  2, Ludwig-Serge Aho-Glélé  8, Olivier Chevallier  9, Marc Sapoval  5

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作者单位

  • 1 Department of Vascular and Interventional Radiology, Image-Guided Therapy Center, François-Mitterrand University Hospital, 21079 Dijon, France; ICMUB Laboratory, UMR CNRS 6302, University of Burgundy, 21000 Dijon, France. Electronic address: romaric.loffroy@chu-dijon.fr.
  • 2 Medical Imaging Department, Hôpital Henri-Mondor, AP-HP, 94000 Créteil, France.
  • 3 Interventional Radiology Section, Department of Medical Imaging, Timone University Hospital, AP-HM, 13385 Marseille, France; Aix Marseille Université, LIIE & CERIMED, 13005 Marseille, France.
  • 4 Department of Medical Imaging, IPI Plateform, Nîmes University Hospital, 30029 Nîmes, France.
  • 5 Department of Vascular and Oncological Interventional Radiology, Hôpital Européen Georges-Pompidou, AP-HP, 75015 Paris, France; Université Paris Cité, PARCC-INSERM Unité 970, 75015 Paris, France.
  • 6 Department of Vascular and Oncological Interventional Radiology, Hôpital Européen Georges-Pompidou, AP-HP, 75015 Paris, France.
  • 7 Department of Radiology, Montpellier University Hospital-Arnaud de Villeneuve, 34090 Montpellier, France.
  • 8 Department of Epidemiology and Biostatistics, François-Mitterrand University Hospital, 21079 Dijon, France.
  • 9 Department of Vascular and Interventional Radiology, Image-Guided Therapy Center, François-Mitterrand University Hospital, 21079 Dijon, France; ICMUB Laboratory, UMR CNRS 6302, University of Burgundy, 21000 Dijon, France.

    • DOI: 10.1016/j.diii.2025.02.001 PMID: 39952827

    摘要 Ai翻译

    Purpose: The purpose of this study was to evaluate the safety and efficacy of a novel ethylene-vinyl alcohol copolymer-based non-adhesive liquid embolic agent for transcatheter arterial embolization (TAE) in patients with bleeding from abdominal and/or pelvic arteries MATERIALS AND METHODS: A prospective observational multicenter study (Clinicaltrials.gov Identifier: NCT04787120) included consecutive patients treated with TAE using a novel ethylene-vinyl alcohol copolymer-based non-adhesive liquid embolic agent (SQUIDPERI 18) at four university hospitals from 2021 to 2023. The indication for TAE included acute symptomatic bleeding or imminent risk of bleeding from visceral (n = 63), muscular (n = 23), or gastrointestinal (n = 29) abdominal/pelvic arteries combined with angiographic abnormalities. Patient characteristics, clinical success rates, and interventional-radiologist satisfaction with each TAE were assessed. Clinical success at 1- and 6 months was defined as survival without reintervention for rebleeding from the initially embolized site(s). Univariable and multivariable analyses were performed to identify variables associated with clinical failure of TAE.

    Results: Of the 110 patients enrolled, 104 had 1-month and 98 had 6-month data. Target vessel(s) were successfully occluded in 108 of the 110 patients, resulting in a technical success rate of 98.2 %. Clinical success rates at 1 and 6 months were 72.1 % (75/104 patients) and 64.3 % (63/98 patients), respectively. Mortality was 20/104 (19.2 %) at 1 month and 26/98 (26.5 %) at 6 months. One patient experienced an adverse event during TAE. The rates of adverse events and serious adverse events at 1 month were 31.4 % (32/102) and 22.5 % (23/102), respectively. Older age was the single variable associated with clinical failure of TAE at 1 month in both univariable and multivariable analysis. In more than 90 % of TAEs, the interventional radiologists were satisfied for five of the seven questionnaire items.

    Conclusion: The novel ethylene-vinyl alcohol copolymer-based non-adhesive liquid embolic agent is safe and effective for TAE in patients presenting with acute symptomatic bleeding from abdominal/pelvic arteries.

    Keywords: Bleeding; Ethylene-vinyl alcohol copolymer; Hemorrhage; Peripheral embolization; Prospective studies.

    Keywords：liquid embolic agent

    关键词：液态栓塞剂; 乙烯-乙烯醇共聚物; 经导管动脉栓塞术; 腹部/盆腔动脉出血

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    期刊名：Diagnostic and interventional imaging

    缩写：DIAGN INTERV IMAG

    ISSN：2211-5684

    e-ISSN：2211-5684

    IF/分区：8.1/Q1

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    Ethylene-vinyl alcohol copolymer-based non-adhesive liquid embolic agent for transcatheter arterial embolization in patients with abdominal/pelvic arterial bleeding: A prospective, single-arm, multicenter cohort study