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SOCS1 protects acute myeloid leukemia against allogeneic T cell-mediated cytotoxicity

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Despite the curative potential of allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia (AML), its efficacy is limited by intrinsic resistance of cancer cells to donor-derived T-cell cytotoxicity. Using a genome-wide CRISPR screen, we i... ...