Streamlined modular synthesis of saframycin substructure via copper-catalyzed three-component assembly and gold-promoted 6- endo cyclization
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The integration of copper(I)-catalyzed three-component coupling with gold(I)-mediated 6-endo cyclization streamlines the rapid and modular assembly of the substructure of bis-tetrahydroisoquinoline (THIQ) alkaloids. The design of the key synthetic intermediate... ...
