首页 文献索引 SCI期刊 AI助手
首页 正文

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 2025 Jan 26. doi: 10.1002/ohn.1140 1981

Effect of Histamine-2 Receptor Antagonists on Hypocalcemia after Thyroidectomy: A Retrospective Cohort Study and Sensitivity Analysis

组氨H2受体拮抗剂对甲状腺手术后低钙血症影响的回顾性队列研究及敏感性分析 翻译改进

Maxwell Rossip  1, F Jeffrey Lorenz  1, Bao Sciscent  1, Nguyen Truong  1, Chaitanya Nimmagadda  1, Neerav Goyal  1, David Goldenberg  1

作者单位 +展开

作者单位

  • 1 Department of Otolaryngology-Head and Neck Surgery, Penn State College of Medicine, Hershey, Pennsylvania, USA.

    • DOI: 10.1002/ohn.1140 PMID: 39865431

    摘要 Ai翻译

    Objective: The objective of this study is to examine the risk of hypocalcemia after thyroidectomy in patients taking histamine-2 receptor antagonists.

    Study design: Retrospective cohort study.

    Setting: Multicenter, single database.

    Methods: Thirty-four thousand two hundred eighteen patients treated with total thyroidectomy from 2011 to 2022 were identified via the TriNetX Research Network. We compared the incidence of transient (0-1 month and 1-6 months following thyroidectomy) and permanent (6-12 months following thyroidectomy) postthyroidectomy hypocalcemia in patients with and without H2 receptor antagonists. Propensity score matching and sensitivity analysis were done to control for additional risk factors.

    Results: Patients were divided into 2 cohorts: those with an H2 receptor antagonist prescription before surgery (n = 5108) and those without (n = 29,110). 44.9% and 11.6% of thyroidectomy patients taking H2 receptor antagonists had hypocalcemia compared to 38.3% and 8.2% of patients without H2 receptor antagonists at 0 to 1 month and 6 to 12 months, respectively. Patients taking H2 receptor antagonists had a significantly increased risk of experiencing hypocalcemia at 0 to 1 month, 1 to 6 months, and 6 to 12 months. Patients taking H2 receptor antagonists were also at increased risk for visiting the emergency department and receiving intravenous calcium replenishment at 1 and 6 months following surgery. Sensitivity analysis continued to yield significant results at all time points.

    Conclusion: Patients taking H2 receptor antagonists may be at increased risk of short and long-term hypocalcemia after thyroid surgery. This is the first retrospective cohort study examining the risk of hypocalcemia after thyroidectomy in patients taking H2 receptor antagonists.

    Keywords: H2 blocker; H2RA; calcium; histamine‐2 receptor antagonists; hypocalcemia; thyroidectomy.

    Keywords：hypocalcemia; thyroidectomy

    关键词：组胺H2受体拮抗剂; 低钙血症; 甲状腺切除术

    Copyright © Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 中文内容为AI机器翻译，仅供参考！

    相关内容

    期刊名：OTOLARYNGOLOGY-HEAD AND NECK SURGERY

    缩写：OTOLARYNG HEAD NECK

    ISSN：0194-5998

    e-ISSN：1097-6817

    IF/分区：/

    文章目录 更多期刊信息

    全文链接
    官方链接
    PMC全文
    引文链接
    复制
    已复制！
    推荐内容
    Effect of Histamine-2 Receptor Antagonists on Hypocalcemia after Thyroidectomy: A Retrospective Cohort Study and Sensitivity Analysis