A novel small molecule NJH-13 induces pyroptosis via the Ca2+ driven AKT-FOXO1-GSDME signaling pathway in NSCLC by targeting TRPV5
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Introduction: Pyroptosis represents a mode of programmed necrotic cell death (PCD), mediated by members of gasdermin family (GSDMs), such as GSDME. It is emerging as a promising approach for combating cancer. Notably, GSDME is th... ...
