Cryo-EM reveals cholesterol binding in the lysosomal GPCR-like protein LYCHOS
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Cholesterol plays a pivotal role in modulating the activity of mechanistic target of rapamycin complex 1 (mTOR1), thereby regulating cell growth and metabolic homeostasis. LYCHOS, a lysosome-localized G-protein-coupled receptor-like protein, emerges as a chole... ...
