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Yeast surface display of leech hyaluronidase for the industrial production of hyaluronic acid oligosaccharides

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Leech hyaluronidase (LHyal) is a hyperactive hyaluronic acid (HA) hydrolase that belongs to the hyaluronoglucuronidase family. Traditionally, LHyal is extracted from the heads of leeches, but the recent development of the Pichia pastoris recombinant LHyal expr... ...