Background: Exercise has been widely used to improve chemotherapy-induced peripheral neuropathy symptoms in cancer patients in recent years; however, there is insufficient evidence to support the effectiveness of exercise intervention in cancer patients.

Objective: This review aims to comprehensively evaluate the effectiveness of exercise intervention in the management of chemotherapy-induced peripheral neuropathy symptoms in cancer patients and to explore effective exercise intervention characteristics by comparing the effects of different exercise prescriptions.

Methods: Ten databases were systematically searched from published up to May 2024. The studies that met the inclusion criteria were included. The risk of bias was assessed using the Cochrane Collaboration tool. The statistical analyses were performed in Stata 17.0.

Results: A total of 21 studies with 775 participants were included. The pooled results showed that exercise significantly reduced the severity of chemotherapy-induced peripheral neuropathy symptoms; relieved neuropathic pain; enhanced balance function, muscle strength, physical flexibility, and physical endurance; and improved the quality of life of cancer patients with chemotherapy-induced peripheral neuropathy, both compared with patients in the usual care group and with patients' baseline symptoms before exercise. However, no significant improvement in fear of falling was observed.

Conclusions: Exercise is an effective way of managing chemotherapy-induced peripheral neuropathy symptoms. The patient's age, exercise cycles, and frequency can affect the effect of the intervention.

Implications for practice: Oncology nurses can significantly manage chemotherapy-induced peripheral neuropathy symptoms in cancer patients through exercise intervention. Further research is necessary to explore the most suitable characteristics of exercise intervention to achieve optimal intervention effectiveness.

Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

背景： 近年来，运动已被广泛用于改善癌症患者的化疗诱导的外周神经病变症状；然而，缺乏足够的证据来支持对癌症患者进行运动干预的有效性。

目的： 本综述旨在全面评估运动干预在管理癌症患者化疗诱导的外周神经病变症状方面的有效性，并通过比较不同运动处方的效果来探索有效的运动干预特征。

方法： 系统检索了截至2024年5月的十个数据库。符合纳入标准的研究被包括进来。使用Cochrane协作工具评估偏倚风险。统计分析在Stata 17.0中进行。

结果： 共纳入21项研究，涉及775名参与者。汇总结果显示，运动显著减轻了化疗诱导的外周神经病变症状；缓解了神经性疼痛；增强了平衡功能、肌肉力量、身体柔韧性和体能耐力，并提高了患有化疗诱导的外周神经病变的癌症患者的生活质量，与常规护理组患者和患者在运动前的症状基线相比。然而，并未观察到跌倒恐惧感有显著改善。

结论： 运动是管理化疗诱导的外周神经病变症状的有效方法。患者的年龄、运动周期和频率会影响干预的效果。

实践意义： 肿瘤科护士可以通过运动干预显著改善癌症患者化疗诱导的外周神经病变的症状。需要进一步研究来探索实现最佳干预效果的最佳运动干预特征。