Knock-in of a 3' UTR Stop Cassette into the Wnt4 locus increases mRNA expression and leads to ovarian cyst formation
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Wnt4 signaling is critical for mammalian female sex determination, in female reproductive organ development, in follicular and oocyte maturation, and in steroid hormone production. When Wnt4 function is impaired, female embryos undergo partial female to male s... ...
