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Preferential cleavage of the coronavirus defective viral genome by cellular endoribonuclease with characteristics of RNase L

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In testing whether coronavirus defective viral genome 12.7 (DVG12.7) with transcription regulating sequence (TRS) can synthesize subgenomic mRNA (sgmRNA) in coronavirus-infected cells, it was unexpectedly found by Northern blot assay that not only sgmRNA (desi... ...