Introduction: Polycystic ovary syndrome is associated with hypertension in women, but few population studies have examined findings among adolescents. This retrospective study examines PCOS and hypertensive blood pressure in a large adolescent population receiving routine healthcare.

Methods: Among females aged 13-17 years who had a well-child visit with systolic/diastolic blood pressure measured in a Northern California healthcare system (2013-2019), the outcome of hypertensive blood pressure (≥130/80 mmHg) was examined. Polycystic ovary syndrome was based on clinical diagnosis (ICD-9/10 256.4/E28.2) within 1 year of the visit. Overweight and obesity were defined by BMI 85th to <95th percentile and ≥95th percentile, respectively; 1.7% with underweight (<5th percentile) were excluded. Multivariable logistic regression was used to examine the association of polycystic ovary syndrome and hypertensive blood pressure, adjusting for age, race/ethnicity, BMI category, and estimated neighborhood deprivation index. Analyses were conducted in 2023-2024.

Results: The cohort included 224,418 females (mean age 14.9±1.4 years; 34.3% non-Hispanic White, 30.1% Hispanic, 19.5% Asian/Pacific Islander, and 9.7% Black). Overall, 18.7% had overweight and 15.8% had obesity. The prevalence of hypertensive blood pressure was 7.2%, much higher for those with polycystic ovary syndrome (18.2%) versus no polycystic ovary syndrome (7.1%, p<0.001). In adjusted analyses, polycystic ovary syndrome was associated with 1.25-fold greater odds of hypertensive blood pressure (95% CI=1.10, 1.42). Similar findings were seen among the subset with obesity (OR=1.23 [95% CI=1.06, 1.42]).

Conclusions: Nearly 1 in 5 adolescents with polycystic ovary syndrome had hypertensive blood pressure. Polycystic ovary syndrome was associated with 25% increased adjusted odds of hypertensive blood pressure, emphasizing the importance of blood pressure surveillance in this population with higher cardiometabolic risk.

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简介： 多囊卵巢综合征与女性高血压相关，但很少有流行病学研究考察青少年中的这种情况。这项回顾性研究调查了在一个大型接受常规医疗保健的青少年群体中，多囊卵巢综合症和高血压的关系。

方法： 在2013年至2019年间，在北加州的一个医疗系统中进行儿童健康检查并测量收缩压/舒张压的女性中（年龄为13至17岁），研究了高血压（≥130/80 mmHg）的发生情况。多囊卵巢综合症基于临床诊断（ICD-9/10 256.4/E28.2，距离检查日期不超过一年）。超重和肥胖分别定义为BMI在第85至

结果： 该队列包括224,418名女性（平均年龄为14.9±1.4岁；非西班牙裔白人为34.3%，西班牙裔为30.1%，亚洲/太平洋岛民为19.5%，黑人为9.7%）。总体而言，18.7%的人超重，而有15.8%的人肥胖。高血压的患病率为7.2%，多囊卵巢综合症患者（18.2%）明显高于没有该病的女性（7.1%，p

结论： 近五分之一的多囊卵巢综合症青少年患者患有高血压。与没有该病的人相比，患有多囊卵巢综合症者的调整后高血压几率增加了25%，强调了在此具有较高心血管代谢风险人群中进行血压监测的重要性。

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