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Endocrine. 2024 Oct 16. doi: 10.1007/s12020-024-04056-z Q32.92025

Elevated circulating regenerating islet-derived protein 4 levels in patients with metabolic syndrome and related to its key components

代谢综合征患者循环中的再生胰岛衍生蛋白4水平升高并与关键成分相关 翻译改进

Tianjiao Shen  1, Yu Yang  1, Yerui Lai  1, Hongmin Zhang  2, Dongfang Liu  1, Cong Wang  1, Ling Li  3, Weiwei Xu  4, Ke Li  1, Shengbing Li  5, Mengliu Yang  6

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作者单位

  • 1 Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
  • 2 Department of Endocrinology, People's Hospital of Chongqing Liang Jiang New Area, Chongqing, China.
  • 3 Key Laboratory of Diagnostic Medicine (Ministry of Education) and Department of Clinical Biochemistry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
  • 4 Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. xuweiwei@hospital.cqmu.edu.cn.
  • 5 Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. 302122@hospital.cqmu.edu.cn.
  • 6 Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. mengliu.yang@cqmu.edu.cn.

    • DOI: 10.1007/s12020-024-04056-z PMID: 39412609

    摘要 中英对照阅读

    Purpose: Regenerating islet-derived protein 4 (REG4) is a secretory protein that belongs to the C-type lectin superfamily. This study aims to explore the diagnostic value of REG4 as a potential biomarker for metabolic syndrome by analyzing the correlation between serum REG4 levels and metabolic syndrome. Methods: Serum REG4 levels were measu... ...点击完成人机验证后继续浏览

    目的： 再生胰岛衍生蛋白4（REG4）是一种属于C型凝集素超家族的分泌蛋白。本研究旨在通过分析血清REG4水平与代谢综合征之间的相关性，探索REG4作为代谢综合征潜在生物标志物的诊断价值。

    方法： 使用酶联免疫吸附测定（ELISA）测量血清REG4水平。进行生物信息学分析以研究与REG4相关的基因和代谢信号通路。

    结果： 代谢综合征患者组的血清REG4水平显著高于健康对照组（439.7 vs. 422.6 ng/L，p

    结论： REG4可能作为胰岛素抵抗和代谢综合征有价值的生物标志物及潜在治疗靶点。

    临床试验注册号： ChiCTR2000032878.

    关键词： 生物信息学分析；胰岛素抵抗；代谢综合征（MetS）；REG4。

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    期刊名：Endocrine

    缩写：ENDOCRINE

    ISSN：1355-008X

    e-ISSN：1559-0100

    IF/分区：2.9/Q3

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    Elevated circulating regenerating islet-derived protein 4 levels in patients with metabolic syndrome and related to its key components