Combination of the PARPi and ARSi in advanced castration resistant prostate cancer: a review of the recent phase III trials
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Tumors with an impaired ability to repair DNA double-strand breaks by homologous recombination, including those with alterations in breast cancer 1 and 2 (BRCA1 and BRCA2) genes, are very sensitive to blocking DNA single-strand repair by inhibition of the poly... ...
