A series of new benzylideneiminophenylthiazole analogues were designed and synthesized. Common spectroscopic methods, such as FT-IR, ¹H-, ¹³C-NMR, and MASS spectra, and elemental analysis, were used to confirm the molecular structures. Then, the antioxidant, cytotoxicity, and anti-bacterial effects of synthesized analogues were assessed against 2,2-diphenyl-1-picrylhydrazyl (DPPH), three cancer cell lines, and two bacterial strains, respectively. Among the analogues, 7f was detected as the most potent compound for antioxidant activity. Moreover, the compounds 7b, 7f, and 7 g exhibited the maximum cytotoxicity activity against MCF-7, HepG-2, and A549 cell lines, respectively. Finally, 7e showed the highest anti-bacterial activity against both S. aureus and E. coli strains. It was concluded from the antioxidant, cytotoxicity, and anti-bacterial effects that the benzylideneiminophenylthiazoles might serve as candidate molecules for the development of small molecules with medicinal potential.

Keywords: Antimicrobial; Antioxidant; Cytotoxicity; Neoplasm.

© 2024. The Author(s).

一系列新的苯并烯亚胺取代的苯并噻唑类似物被设计和合成。使用常见的光谱方法，如傅里叶变换红外光谱（FT-IR）、¹H-NMR、¹³C-NMR 和质谱以及元素分析来确认分子结构。然后，评估了这些合成化合物对2,2-二苯基-1-苦味酸肼(DPPH)、三种癌细胞系和两种细菌菌株的抗氧化、细胞毒性和抗菌活性。在所有类似物中，7f 被检测为抗氧化活性最强的化合物。此外，化合物 7b、7f 和 7g 分别对 MCF-7、HepG-2 和 A549 细胞系表现出最大的细胞毒性作用。最后，7e 对金黄色葡萄球菌和大肠杆菌两种菌株显示出最高的抗菌活性。从抗氧化、细胞毒性和抗菌效果来看，苯并烯亚胺取代的苯并噻唑可能作为具有药物潜力的小分子候选化合物。

关键词： 抗微生物；抗氧化；细胞毒性；肿瘤。

© 2024. The Author(s).