Preexisting senescent fibroblasts in the aged bladder create a tumor-permissive niche through CXCL12 secretion
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Aging is a major risk factor for cancer, but the precise mechanism by which aging promotes carcinogenesis remains largely unknown. Here, using genetically modified mouse models, we show that p16high senescent (p16h-sn) fibroblasts accumulate with age, constitu... ...
