Robustaflavone as a novel scaffold for inhibitors of native and auto-proteolysed human neutrophil elastase
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Human neutrophil elastase (HNE) plays a key role in initiating inflammation in the cardiopulmonary and systemic contexts. Pathological auto-proteolysed two-chain (tc) HNE exhibits reduced binding affinity with inhibitors. Using AutoDock Vina v1.2.0, 66 flavono... ...