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RET is a sex-biased regulator of intestinal tumorigenesis

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Ret is implicated in colorectal cancer (CRC) as both a proto-oncogene and a tumor suppressor. We asked whether RET signaling regulates tumorigenesis in an Apc-deficient preclinical model of CRC. We observed a sex-biased phenotype: Apc Min/+ Ret+/- females had ... ...