Objective: Accumulating evidence indicates that oxidative stress and the disruption of antioxidant defenses play an important role in the neurobiology of bipolar disorder (BD). Studies have found that increased oxidative stress may be associated with cell apoptosis and neuronal damage in BD patients. Hence, this study explored the research field related to BD and oxidative stress from a bibliometrics perspective.

Methods: Literature search and relevant data retrieval based on the Web of Sciences Core Collection (WoSCC). R software (version 4.2.2), VOSviewer software (version 1.6.18), and CiteSpace (version 6.1.6) were used in this bibliometric analysis.

Results: A total of 2081 publications related to BD and oxidative stress were published between 1986 and 2024. Bipolar Disorders was the journal that had the most publications in this area (72; 3.46%; IF = 5.9), while the United States (1285; 61.7%) and the University of Toronto (377; 18.1%) were the most productive country and institution, respectively. Apart from "oxidative stress" and "bipolar disorder," the most frequently used keywords were "schizophrenia," "prefrontal cortex," and "nitric oxide."

Conclusions: The growing number of publications related to BD and oxidative stress in recent years highlights the importance of this research field. Hot topics in research related to BD and oxidative stress included animal experiments and molecular mechanisms, psychiatric-related inflammation and biomarkers, neurodegenerative diseases, and metabolism. Furthermore, the biological mechanisms of BD, particularly biomarkers and inflammation, may be the emerging research priority area in the future.

Keywords: VOSviewer; bibliometric analysis; bipolar disorder; nitric oxide; oxidative stress.

© 2024 The Author(s). Asia‐Pacific Psychiatry published by John Wiley & Sons Australia, Ltd.

目标： 累积的证据表明，氧化应激和抗氧化防御系统的破坏在双相障碍（BD）的神经生物学中起着重要作用。研究表明，增加的氧化应激可能与BD患者的细胞凋亡和神经元损伤有关。因此，本研究从文献计量学的角度探讨了与BD和氧化应激相关的研究领域。

方法： 基于Web of Sciences Core Collection (WoSCC) 进行文献检索和相关数据的获取。该文献计量分析使用了R软件（版本4.2.2），VOSviewer软件（版本1.6.18）以及CiteSpace（版本6.1.6）。

结果： 在1986年至2024年间，共有2081篇与BD和氧化应激相关的出版物。双相障碍期刊在此领域发表的论文数量最多（72篇；占3.46%；影响因子=5.9），美国（1285篇；占比61.7%）和多伦多大学（377篇；占比18.1%）分别是该领域的最活跃国家和机构。除了“氧化应激”和“双相障碍”，使用频率最高的关键词是“精神分裂症”、“前额叶皮层”和“一氧化氮”。

结论： 近年来与BD和氧化应激相关的出版物数量不断增加，突显了这一研究领域的重要性。与此相关的研究热点包括动物实验和分子机制、精神疾病相关的炎症和生物标志物、神经退行性疾病以及代谢。此外，未来可能的新兴研究优先领域可能是BD的生物学机制，特别是生物标志物和炎症。

关键词： VOSviewer；文献计量分析；双相障碍；一氧化氮；氧化应激。