Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria
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Malaria remains a global health concern as drug resistance threatens treatment programs. We identified a piperidine carboxamide (SW042) with anti-malarial activity by phenotypic screening. Selection of SW042-resistant Plasmodium falciparum (Pf) parasites revea... ...
