Dissecting the neuroprotective interaction between the BH4 domain of BCL-w and the IP3 receptor
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BCL-w is a BCL-2 family protein that promotes cell survival in tissue- and disease-specific contexts. The canonical anti-apoptotic functionality of BCL-w is mediated by a surface groove that traps the BCL-2 homology 3 (BH3) α-helices of pro-apoptotic members,... ...
