4-hydroxy-2-oxoglutarate metabolism in a mouse model of Primary Hyperoxaluria Type 3
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Primary Hyperoxaluria Type 3 (PH3) results from 4-hydroxy-2-oxoglutarate (HOG) aldolase (HOGA) deficiency, which causes an increase in endogenous oxalate synthesis leading to calcium oxalate kidney stone disease. The mechanisms underlying HOG metabolism and in... ...
