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Preparation and in vivo and ex vivo studies of sirolimus nano-in-situ gel ophthalmic formulation

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Sirolimus (SR) is a macrolide with antifungal and antitumor immunosuppressant properties, classified as a selective inhibitor of mammalian target of rapamycin (mTOR). In this study, an ionic in situ gel of SR (SR-SUS-ISG) was formulated using gellan gum, exhib... ...