Histone H2A deubiquitinase BAP1 is essential for endothelial cell differentiation from human pluripotent stem cells
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Polycomb group proteins (PcGs) add repressive post translational histone modifications such as H2AK119ub1, and histone H2A deubiquitinases remove it. Mice lacking histone H2A deubiquitinases such as Usp16 and Bap1 die in embryonic stage, while mice lacking Usp... ...