In vitro evaluation of novel SN-38 prodrug activated by α-rhamnosidase of exogenous enzyme
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This study introduces the α-rhamnose (Rham)-conjugated prodrug of SN-38 (Rham-SN-38) as a promising alternative to irinotecan. α-rhamnosidase, responsible for SN-38 release from Rham-SN-38, does not express in human cells, minimizing individual variability a... ...
