Yeast Prion Protein Sup35 Initiates α-Synuclein Pathology in Parkinson's Disease
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Sinus infection of Saccharomyces cerevisiae accelerates the aggregation of α-synuclein (α-syn) in A53T mice, which was caused by prion protein Sup35. Sup35 promotes α-syn aggregation in vitro and in vivo and leads to Parkinson's disease (PD)-like motor impa... ...
