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The activation mechanism of Atg15, a vacuolar phospholipase required for the disintegration of organelle membranes

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The disintegration of cytoplasm-to-vacuole targeting (Cvt) bodies and autophagic bodies in vacuoles is essential to the Cvt pathway and macroautophagy in yeast. Atg15 is a vacuolar lipase required for the degradation of both Cvt and autophagic bodies. However,... ...