Discovery of hematopoietic progenitor kinase 1 inhibitors using machine learning-based screening and free energy perturbation
{{output}}
Hematopoietic progenitor kinase 1 (HPK1) is a key negative regulator of T-cell receptor (TCR) signaling and a promising target for cancer immunotherapy. The development of novel HPK1 inhibitors is challenging yet promising. In this study, we used a combination... ...
