Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM
{{output}}
Clamp loaders are AAA+ ATPases that facilitate high-speed DNA replication. In eukaryotic and bacteriophage clamp loaders, ATP hydrolysis requires interactions between aspartate residues in one protomer, present in conserved 'DEAD-box' motifs, and arginine resi... ...
