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Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging

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Autophagy is a lysosome-dependent degradation pathway essential for cellular homeostasis, which decreases with age. However, it is unclear how aging induces autophagy decline. Here we show the role of protein S-palmitoylation in autophagy. We identify the palm... ...