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Engagement of CD300c by a novel monoclonal antibody induces the differentiation of monocytes to M1 macrophages

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Human CD300c is expressed on various immune or cancer cells and is a novel B7 family member, functioning as an activity modulator on immune cells. To elucidate the function of CD300c, we developed CL7, a human CD300c-specific monoclonal antibody, and assessed ... ...