Human retinal organoids with an OPA1 mutation are defective in retinal ganglion cell differentiation and function
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Autosomal dominant optic atrophy (ADOA), mostly caused by heterozygous OPA1 mutations and characterized by retinal ganglion cell (RGC) loss and optic nerve degeneration, is one of the most common types of inherited optic neuropathies. Previous work using a two... ...
