Selective and brain-penetrant HCN1 inhibitors reveal links between synaptic integration, cortical function, and working memory
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Hyperpolarization-activated and cyclic-nucleotide-gated 1 (HCN1) ion channels are proposed to be critical for cognitive function through regulation of synaptic integration. However, resolving the precise role of HCN1 in neurophysiology and exploiting its thera... ...
