Improved characterization of trastuzumab deruxtecan with PTCR and internal fragments implemented in middle-down MS workflows
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Antibody-drug conjugates (ADCs) are highly complex proteins mainly due to the structural microvariability of the mAb, along with the additional heterogeneity afforded by the bioconjugation process. Top-down (TD) and middle-down (MD) strategies allow the straig... ...
